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What is a Beta Amyloid?

Beta-amyloid, often stylized as beta-amyloid (Aβ), is a protein fragment snipped from an amyloid precursor protein (APP). In a healthy brain, these protein fragments are broken down and eliminated. However, in Alzheimer's disease, the fragments accumulate to form hard, insoluble plaques. These plaques are one of the hallmarks of the disease, contributing to the degradation of neurons in the brain and leading to the symptoms of dementia. According to the Alzheimer's Association, Alzheimer's disease accounts for 60-80% of dementia cases, making the understanding of beta-amyloid crucial in the quest to combat this debilitating condition.


Research has shown that the accumulation of beta-amyloid can begin years before the appearance of clinical symptoms of Alzheimer's. This has led to the hypothesis that beta-amyloid plaques play a critical role in the disease's onset and progression. Studies, such as those reported by the National Institute on Aging, suggest that the presence of these plaques can interfere with neuron-to-neuron communication and activate immune system cells that trigger inflammation and devour disabled cells. The complexity of beta-amyloid interactions within the brain underscores the importance of ongoing research to fully understand and effectively target Alzheimer's disease.

Emma Lloyd
Emma Lloyd

The beta amyloid protein is a large peptide containing between 39 and 43 amino acids. This peptide chain is thought to play a major role in the development of Alzheimer’s disease. The plaques which develop in the brains of people with Alzheimer’s are composed primarily of the beta amyloid peptide. This peptide may also play a role in the development of other neurological diseases such as Lewy body dementia.

Beta amyloid plaques are formed primarily from a peptide that is 42 amino acids long. The more common form of the peptide has only 40 amino acids, but the 42AA peptide has a greater tendency to form plaques. The plaques form because the protein is fibrillogenic, meaning that it has a tendency to clump together with other like proteins to form fibrous structures. These structures are the plaques which progressively inhibit normal brain function in people with Alzheimer’s disease.

Beta amyloids may play a role in dementia.
Beta amyloids may play a role in dementia.

Research suggests that the plaques cause dementia because these peptide fiber clumps attach themselves to neurons in the brain. Once attached, the fibers prevent the neurons from receiving signals from other cells in the brain. The affected neurons cannot function or communicate with other brain cells, and die as a result.

Alzheimer’s is partially genetically inherited, a trait which is associated with the tendency to produce beta amyloid peptides that are 42 amino acids in length. When an individual has one copy of the gene which produces the 42AA peptide, he or she has an increased risk of developing Alzheimer’s disease. A person with two copies of this gene is at high risk of developing early-onset Alzeimer’s.

Research suggests that peptide fiber clumps attach themselves to neurons in the brain, causing dementia.
Research suggests that peptide fiber clumps attach themselves to neurons in the brain, causing dementia.

Based on this knowledge of how the protein interacts to form plaques, researchers have come up with several ideas which are under investigation as potential therapies to treat Alzheimer’s disease. One of these is an enzyme called a beta-secretase inhibitor. This enzyme may be able to block cleavage of the amyloid protein into the 42AA form which is most strongly associated with the development of Alzheimer’s. A related idea is a gamma-secretase enzyme, which prevents formation of the 42AA peptide at another point in the production cycle.

Beta amyloids play a major role in the development of development of Alzheimer’s disease.
Beta amyloids play a major role in the development of development of Alzheimer’s disease.

Another approach to treat Alzheimer’s is the development of a beta amyloid antibody which can recognize and bind to the 42AA peptide. These antibodies may be able to bind to the peptide and prevent it from forming plaques. In addition, the antibody can help promote the destruction of the peptide, as the immune system will destroy the antibody-peptide complexes that form.

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Discussion Comments

anon280018

Are beta amyloid peptides also responsible for giving after-stroke aphasia? Is there any connection between Alzheimer's and aphasia? Is there any remedy whatsoever for aphasia? -- Firoz

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    • Beta amyloids may play a role in dementia.
      By: xalanx
      Beta amyloids may play a role in dementia.
    • Research suggests that peptide fiber clumps attach themselves to neurons in the brain, causing dementia.
      By: designua
      Research suggests that peptide fiber clumps attach themselves to neurons in the brain, causing dementia.
    • Beta amyloids play a major role in the development of development of Alzheimer’s disease.
      By: Konstantin Sutyagin
      Beta amyloids play a major role in the development of development of Alzheimer’s disease.
    • Amyloid is a type of fibrous protein build-up that is the biological hallmark of an Alzheimer's-affected brain.
      By: godfer
      Amyloid is a type of fibrous protein build-up that is the biological hallmark of an Alzheimer's-affected brain.